Innate Lymphoid Cells in the Central Nervous System

Shuaiwei Wang (1) , Serge van de Pavert (1)

1 CIML - Centre d'Immunologie de Marseille - Luminy

Immune cells are present within the central nervous system and play important roles in neurological inflammation and disease. As relatively new described immune cell population, Innate Lymphoid Cells are now increasingly recognized within the central nervous system and associated diseases. Innate Lymphoid Cells are generally regarded as tissue resident and early responders, while conversely within the central nervous system at steady-state their presence is limited. This review describes the current understandings on Innate Lymphoid Cells in the central nervous system at steady-state and its borders plus their involvement in major neurological diseases like ischemic stroke, Alzheimer’s disease and Multiple Sclerosis.

Mots clés: NK; ILC1; ILC2; ILC3; ischemic stroke; Alzheimer’s disease; multiple sclerosis; glioma

Domaines: Sciences du Vivant [q-bio]

Shuaiwei Wang, Serge van de Pavert. Innate Lymphoid Cells in the Central Nervous System. Frontiers in Immunology, 2022, 13, ⟨10.3389/fimmu.2022.837250⟩. ⟨hal-03670641⟩