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Instructive Cues of Thymic T Cell Selection

Abstract : A high diversity of αβ T cell receptors (TCRs), capable of recognizing virtually any pathogen but also self-antigens, is generated during T cell development in the thymus. Nevertheless, a strict developmental program supports the selection of a self-tolerant T cell repertoire capable of responding to foreign antigens. The steps of T cell selection are controlled by cortical and medullary stromal niches, mainly composed of thymic epithelial cells and dendritic cells. The integration of important cues provided by these specialized niches, including ( a) the TCR signal strength induced by the recognition of self-peptide-MHC complexes, ( b) costimulatory signals, and ( c) cytokine signals, critically controls T cell repertoire selection. This review discusses our current understanding of the signals that coordinate positive selection, negative selection, and agonist selection of Foxp3 + regulatory T cells. It also highlights recent advances that have unraveled the functional diversity of thymic antigen-presenting cell subsets implicated in T cell selection.
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Submitted on : Tuesday, May 17, 2022 - 4:02:07 PM
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Magali Irla. Instructive Cues of Thymic T Cell Selection. Annual Review of Immunology, Annual Reviews, 2022, 40 (1), pp.95-119. ⟨10.1146/annurev-immunol-101320-022432⟩. ⟨hal-03670661⟩



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