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Article Dans Une Revue Optics Express Année : 2022

Label-free highly multimodal nonlinear endoscope

Résumé

We demonstrate a 2 mm diameter highly multimodal nonlinear micro-endoscope allowing label-free imaging of biological tissues. The endoscope performs multiphoton fluorescence (3-photon, 2-photon), harmonic generation (second-SHG and third-THG) and coherent anti-Stokes Raman scattering (CARS) imaging over a field of view of 200 µm. The microendoscope is based on a double-clad antiresonant hollow core fiber featuring a high transmission window (850 nm to 1800 nm) that is functionalized with a short piece of graded-index (GRIN) fiber. When combined with a GRIN micro-objective, the micro-endoscope achieves a 1.1 µm point spread function (PSF). We demonstrate 3-photon, 2-photon, THG, SHG, and CARS high resolution images of unlabelled biological tissues.
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hal-03706852 , version 1 (28-06-2022)

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D Septier, V Mytskaniuk, R Habert, D Labat, K Baudelle, et al.. Label-free highly multimodal nonlinear endoscope. Optics Express, 2022, 30, ⟨10.1364/oe.462361⟩. ⟨hal-03706852⟩
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