Endocardial Regulation of Cardiac Development

Lara Feulner (1) , Patrick Piet Van Vliet (1) , Michel Puceat (2) , Gregor Andelfinger (1)

1 Centre de recherche du CHU Sainte-Justine / Research Center of the Sainte-Justine University Hospital [Montreal, Canada]
2 MMG - Marseille medical genetics - Centre de génétique médicale de Marseille

The endocardium is a specialized form of endothelium that lines the inner side of the heart chambers and plays a crucial role in cardiac development. While comparatively less studied than other cardiac cell types, much progress has been made in understanding the regulation of and by the endocardium over the past two decades. In this review, we will summarize what is currently known regarding endocardial origin and development, the relationship between endocardium and other cardiac cell types, and the various lineages that endocardial cells derive from and contribute to. These processes are driven by key molecular mechanisms such as Notch and BMP signaling. These pathways in particular have been well studied, but other signaling pathways and mechanical cues also play important roles. Finally, we will touch on the contribution of stem cell modeling in combination with single cell sequencing and its potential translational impact for congenital heart defects such as bicuspid aortic valves and hypoplastic left heart syndrome. The detailed understanding of cellular and molecular processes in the endocardium will be vital to further develop representative stem cell-derived models for disease modeling and regenerative medicine in the future.

Mots clés: endocardium; heart development; heart disease; BMP; Notch

Domaines: Génétique

Lara Feulner, Patrick Piet Van Vliet, Michel Puceat, Gregor Andelfinger. Endocardial Regulation of Cardiac Development. Journal of Cardiovascular Development and Disease, 2022, 9 (5), ⟨10.3390/jcdd9050122⟩. ⟨hal-03780347⟩