Association between adherence to the EAT-Lancet diet and risk of cancer and cardiovascular outcomes in the prospective NutriNet-Santé cohort - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue The American Journal of Clinical Nutrition Année : 2022

Association between adherence to the EAT-Lancet diet and risk of cancer and cardiovascular outcomes in the prospective NutriNet-Santé cohort

Association entre l'adhérence au régime de référence EAT-Lancet et le risque de survenue de cancer et de maladies cardiovasculaires dans la cohorte NutriNet-Santé.

Philippe Pointereau
  • Fonction : Auteur
  • PersonId : 1034461
  • IdRef : 034342419

Résumé

Background: The EAT-Lancet commission proposed, in 2019, a planetary, healthy, and universal dietary pattern. However, this diet has rarely been studied in relation to various health outcomes. Objectives: We aimed to prospectively estimate the association between the EAT-Lancet diet and cancer and cardiovascular disease (CVD) risk. Methods: The study was conducted in participants of the NutriNet-Santé cohort (2009–2021). The endpoints were the incident outcomes (cancer and CVDs and mortality from these diseases), combined and separately. Adherence to the EAT-Lancet diet was estimated using the EAT-Lancet Diet Index (ELD-I) modeled as quintiles (Qs). Multivariable Cox proportional hazard models were used to estimate HRs and 95% CIs, adjusted for potential confounders and moderators. Results: A total of 62,382 subjects were included; 2475 cases of cancer and 786 cases of cardiovascular events occurred during a median follow-up of 8.1 y. The sample was 76% female, the mean ± SD age at inclusion was 51.0 ± 10.2 y. The ELD-I ranged from −162 to 332 points with a mean ± SD score of 45.4 ± 25.6 points. In multivariable models, no significant association between the EAT-Lancet diet and the risk of cancer and CVD combined, and separately, was observed. Alcohol consumption was an effect modifier of the association. A significant association was observed among low drinkers (HRQ5vs.Q1: 0.86; 95% CI: 0.73, 1.02; P-trend = 0.02). A higher ELD-I was significantly associated with a lower risk of overall cancer only among females (HRQ5vs.Q1: 0.89; 95% CI: 0.75, 1.05; P-trend = 0.03). Both associations were largely attenuated by BMI. Conclusions: Contrary to our hypothesis, our results documented significant associations between adherence to the EAT-Lancet diet and incidence of cancer only in some subgroups, and no association with CVD.
Fichier principal
Vignette du fichier
EAT-Lancet and chronic dis_ manuscript_ BERTHY_revised.pdf (831.12 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03786830 , version 1 (23-09-2022)

Identifiants

Citer

Florine Berthy, Joséphine Brunin, Benjamin Allès, Léopold Fezeu, Mathilde Touvier, et al.. Association between adherence to the EAT-Lancet diet and risk of cancer and cardiovascular outcomes in the prospective NutriNet-Santé cohort. The American Journal of Clinical Nutrition, inPress, 116 (4), pp.980-991. ⟨10.1093/ajcn/nqac208⟩. ⟨hal-03786830⟩
194 Consultations
144 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More