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Three-year outcome of local injection of autologous stromal vascular fraction cells and microfat in refractory perianal fistulas of Crohn’s disease

Abstract : Abstract Perianal fistulas in Crohn's disease are frequent and disabling, with a major impact on patients' quality of life. Cell-based therapy using mesenchymal stem cells represents new hope for these patients, but long-term efficacy remains challenging. In a pilot study, including patients with refractory complex perianal fistulas, autologous adipose-derived stromal vascular fraction (ADSVF) combined with microfat achieved combined remission in 60% of cases, with a good safety profile at 1 year. The purpose of this study is to assess whether these results were maintained at longer term. The safety and efficacy data of the ten patients were evaluated retrospectively 3 years after injection on the basis of clinical and radiological data. MRI were analysed according to the MAGNIFI-CD score. No adverse event was attributed to the experimental stem-cell treatment. Combined remission was achieved in 7 patients (70%) and associated with a significant improvement in the MAGNIFI-CD MRI score. In conclusion, the safety and efficacy of ADSVF and microfat injection in Crohn's disease fistulas were maintained at 3 years, demonstrating that this innovative strategy is effective in producing a long-lasting healing effect. The ongoing multicentre randomized placebo-controlled trial (NCT04010526) will be helpful to define the place for this approach in the current therapeutic arsenal.
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https://hal-amu.archives-ouvertes.fr/hal-03791950
Contributor : GUILLAUME RANCHON Connect in order to contact the contributor
Submitted on : Thursday, September 29, 2022 - 4:25:07 PM
Last modification on : Friday, September 30, 2022 - 4:11:42 AM

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Lucas Guillo, Fanny Grimaud, Fanny Houser, Caroline Prost, Elisabeth Jouve, et al.. Three-year outcome of local injection of autologous stromal vascular fraction cells and microfat in refractory perianal fistulas of Crohn’s disease. Current Stem Cell Research & Therapy, 2022, 13 (1), pp.67. ⟨10.1186/s13287-022-02738-x⟩. ⟨hal-03791950⟩

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