Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior

Natalia Popa (1) , Dipankar Bachar (1) , Angela C. Roberts (2) , Andrea M Santangelo (2) , Eduardo Gascon (1)

1 AMU - Aix Marseille Université
2 CAM - University of Cambridge [UK]

Psychiatric diseases such as depression and anxiety are multifactorial conditions, highly prevalent in western societies. Human studies have identified a number of high-risk genetic variants for these diseases. Among them, polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) have attracted much attention. However, due to the paucity of experimental models, molecular alterations induced by these genetic variants and how they correlate to behavioral deficits have not been examined. In this regard, marmosets have emerged as a powerful model in translational neuroscience to investigate molecular underpinnings of complex behaviors.

Keywords: anxiety; depression; non-human primates; marmoset; microRNA; ventro-medial prefrontal cortex; DCC

Domains: Neurons and Cognition [q-bio.NC]

Natalia Popa, Dipankar Bachar, Angela C. Roberts, Andrea M Santangelo, Eduardo Gascon. Region-specific microRNA alterations in marmosets carrying SLC6A4 polymorphisms are associated with anxiety-like behavior. EBioMedicine, 2022. ⟨hal-03795601⟩