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Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy

Abstract : Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI (23 Na MRI) and 1 H-MR Spectroscopic Imaging (1 H-MRSI), assessing changes within epileptogenic networks in comparison with electrophysiologically normal networks as defined by stereotactic EEG (SEEG) recordings analysis. We applied a multi-echo density adapted 3D projection reconstruction pulse sequence at 7 T (23 Na-MRI) and a 3D echo-planar spectroscopic imaging sequence at 3 T (1 H-MRSI) in 19 patients suffering from drugresistant focal epilepsy who underwent presurgical SEEG. We investigated 23 Na MRI parameters including total sodium concentration (TSC) and the sodium signal fraction associated with the short component of T 2 * decay (f), alongside the level of metabolites N-acetyl aspartate (NAA), choline compounds (Cho), and total creatine (tCr). All measures were extracted from spherical regions of interest (ROIs) centered between two adjacent SEEG electrode contacts and z-scored against the same ROI in controls. Group comparison showed a significant increase in f only in the epileptogenic zone (EZ) compared to controls and compared to patients' propagation zone (PZ) and noninvolved zone (NIZ). TSC was significantly increased in all patients' regions compared to controls. Conversely, NAA levels were significantly lower in patients compared to controls, and lower in the EZ compared to PZ and NIZ. Multiple regression analyzing the relationship between sodium and metabolites levels revealed significant relations
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https://hal-amu.archives-ouvertes.fr/hal-03811157
Contributor : Jean-Philippe RANJEVA Connect in order to contact the contributor
Submitted on : Tuesday, October 11, 2022 - 4:50:13 PM
Last modification on : Thursday, October 13, 2022 - 11:21:01 AM

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Mikhael Azilinon, Julia Makhalova, Wafaa Zaaraoui, Samuel Medina Villalon, Patrick Viout, et al.. Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy. Human Brain Mapping, In press, ⟨10.1002/hbm.26102⟩. ⟨hal-03811157⟩

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