Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Pflügers Archiv European Journal of Physiology Année : 2021

Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle

Medical image segmentation automatic quality control: A multi-dimensional approach

Jae Mo Park
Sonal Josan
  • Fonction : Auteur
Ralph Hurd
  • Fonction : Auteur
James Graham
  • Fonction : Auteur
Peter Havel
  • Fonction : Auteur
Dirk Mayer
  • Fonction : Auteur
Youngran Chung
  • Fonction : Auteur
Daniel Spielman
  • Fonction : Auteur
Thomas Jue

Résumé

The main finding of the present study was that the metabolic changes associated with a moderate-intensity muscle exercise were slightly modified in stable sickle cell anemia patients and sickle cell trait carriers as compared to controls but still in the normal range. The present results strongly support the safety of a moderate-intensity exercise for stable sickle cell anemia patients and sickle cell trait carriers.

Dates et versions

hal-03818772 , version 1 (09-01-2024)

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Citer

Jae Mo Park, Sonal Josan, Ralph Hurd, James Graham, Peter Havel, et al.. Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle. Pflügers Archiv European Journal of Physiology, 2021, 473 (11), pp.1761-1773. ⟨10.1007/s00424-021-02613-3⟩. ⟨hal-03818772⟩
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