Skip to Main content Skip to Navigation
New interface
Journal articles

Tau Protein as Therapeutic Target for Cancer? Focus on Glioblastoma

Abstract : Despite being extensively studied for several decades, the microtubule-associated protein Tau has not finished revealing its secrets. For long, Tau has been known for its ability to promote microtubule assembly. A less known feature of Tau is its capability to bind to cancer-related protein kinases, suggesting a possible role of Tau in modulating microtubule-independent cellular pathways that are associated with oncogenesis. With the intention of finding new therapeutic targets for cancer, it appears essential to examine the interaction of Tau with these kinases and their consequences. This review aims at collecting the literature data supporting the relationship between Tau and cancer with a particular focus on glioblastoma tumors in which the pathological significance of Tau remains largely unexplored. We will first treat this subject from a mechanistic point of view showing the pivotal role of Tau in oncogenic processes. Then, we will discuss the involvement of Tau in dysregulating critical pathways in glioblastoma. Finally, we will outline promising strategies to target Tau protein for the therapy of glioblastoma.
Complete list of metadata

https://hal-amu.archives-ouvertes.fr/hal-03837788
Contributor : François Devred Connect in order to contact the contributor
Submitted on : Thursday, November 3, 2022 - 10:29:38 AM
Last modification on : Saturday, November 5, 2022 - 3:17:52 AM

File

40 cancers-14-05386.pdf
Publisher files allowed on an open archive

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Rayane Hedna, Hervé Kovacic, Alessandra Pagano, Vincent Peyrot, Maxime Robin, et al.. Tau Protein as Therapeutic Target for Cancer? Focus on Glioblastoma. Cancers, 2022, 14 (21), pp.5386. ⟨10.3390/cancers14215386⟩. ⟨hal-03837788⟩

Share

Metrics

Record views

0

Files downloads

0