Ultrasonic-assisted-synthesis of isoindolin-1-one derivatives

Muhammad Idham Darussalam Mardjan (1) , Muhamad Fadhly Hariadi (1) , Indah Mutiara Putri (1) , Nilna Amalia Musyarrofah (1) , Muflihah Salimah (1) , Bambang Purwono (1) , Laurent Commeiras (2)

1 Department of Chemistry, Faculty of Mathematics and Natural Science, Gadjah Mada University
2 ISM2 - Institut des Sciences Moléculaires de Marseille

A small library of 3-hydroxyisoindolin-1-ones has been prepared from 3-alkylidenephtalides under ultrasonic irradiation. This practical synthesis is featured by group tolerance, high efficiency and yields. The reaction can also be performed in multigram scale and be further extended to access other motifs of isoindolin-1-ones in a one-pot fashion.

Keywords: 3-hydroxyisoindolin-1-ones; ultrasonic irradiation ; heterocycles

Domains: Chemical Sciences; Organic chemistry

Muhammad Idham Darussalam Mardjan, Muhamad Fadhly Hariadi, Indah Mutiara Putri, Nilna Amalia Musyarrofah, Muflihah Salimah, et al.. Ultrasonic-assisted-synthesis of isoindolin-1-one derivatives. RSC Advances, 2022, 12 (29), pp.19016-19021. ⟨10.1039/d2ra02720h⟩. ⟨hal-03862577⟩