Preparation of 3‐Alkylidenephthalides: Recent Advances

Julien Petrignet (1) , Jérôme Thibonnet (1) , Laurent Commeiras (2) , David Gueyrard (3)

1 SIMBA - Synthèse et isolement de molécules bio-actives EA 7502
2 ISM2 - Institut des Sciences Moléculaires de Marseille
3 ICBMS - Institut de Chimie et Biochimie Moléculaires et Supramoléculaires

3-Alkylidenephthalides represent an important class of natural compounds which are also valuable synthetic precursors for the preparation of phthalides. While recent reviews reported the great interest of the phthalides in the field of medicinal chemistry, few reports are mentioning the recent progress for the synthesis of their unsaturated homologous in the position 3. So, the aim of this report is to present the latest progresses (since 2010 and until 2021) in the synthesis of 3-alkylidenephtalides.

Keywords: alkylidenephthalide ; cross-coupling ; cyclization ; olefination

Domains: Chemical Sciences; Organic chemistry

Julien Petrignet, Jérôme Thibonnet, Laurent Commeiras, David Gueyrard. Preparation of 3‐Alkylidenephthalides: Recent Advances. European Journal of Organic Chemistry, 2022, 2022 (22), ⟨10.1002/ejoc.202200344⟩. ⟨hal-03862612⟩