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Article Dans Une Revue European Journal of Haematology Année : 2022

Plasma levels of E‐selectin are associated with retinopathy in sickle cell disease

Résumé

Background: The vascular endothelium is markedly disrupted in sickle cell disease (SCD) and is the converging cascade of the complex pathophysiologic processes linked to sickle cell vasculopathy. Circulating endothelial activation and/or apoptotic markers may reflect this endothelial activation/damage that contributes to the pathophysiology of the SCD vascular complications. Methods: Plasmatic levels of circulating endothelial cells (CECs), E-selectin, progenitor's endothelial cells (EPCs), and circulating extracellular vesicles (EVs) were evaluated in 50 SCD patients, 16 with vasculopathy. The association between these markers and the occurrence of disease-related microvascular injuries of the eye (retinopathy), kidney (nephropathy), and skin (chronic active ulcers) was explored. Results: Among the endothelial activation markers studied, only higher plasma levels of E-selectin were found in SCD patients with vasculopathy (p = .015). Increased E-selectin levels were associated with retinopathy (p < .001) but not with nephropathy or leg ulcers. All patients, at steady state, with or without vasculopathy, did not display a high count of CEC and EPC, markers of endothelial injury and repair. We did not show any significant differences in EVs levels between vasculopathy and not vasculopathy SCD patients. Conclusions: Further studies will be required to determine whether the E-selectin could be used as an early biomarker of retinopathy sickle cell development.

Dates et versions

hal-03922604 , version 1 (04-01-2023)

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Imane Agouti, Elodie Masson, Anderson Loundou, Estelle Jean, Laurent Arnaud, et al.. Plasma levels of E‐selectin are associated with retinopathy in sickle cell disease. European Journal of Haematology, 2022, ⟨10.1111/ejh.13902⟩. ⟨hal-03922604⟩
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