Methionine oxidation in bacteria: A reversible post‐translational modification
Résumé
Methionine is a sulfur-containing residue found in most proteins which are particu-
larly susceptible to oxidation. Although methionine oxidation causes protein damage,
it can in some cases activate protein function. Enzymatic systems reducing oxidized
methionine have evolved in most bacterial species and methionine oxidation proves
to be a reversible post-translational modification regulating protein activity. In this
review, we inspect recent examples of methionine oxidation provoking protein loss
and gain of function. We further speculate on the role of methionine oxidation as a
multilayer endogenous antioxidant system and consider its potential consequences
for bacterial virulence.
Domaines
Sciences du Vivant [q-bio]
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Molecular Microbiology - 2022 - Vincent - Methionine oxidation in bacteria A reversible post_E2_80_90translational modification.pdf (714.97 Ko)
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