Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France

Younes Laidoudi (1) , Edgarthe Priscilla Ngaiganam (1) , Jean-Lou Marié (2) , Isabelle Pagnier (1, 3) , Jean-Marc Rolain (1, 3) , Seydina Mouhamadou Diene (1, 3) , Bernard Davoust (3)

1 MEPHI - Microbes évolution phylogénie et infections
2 CESPA - Centre d'épidémiologie et de santé publique des armées [Marseille]
3 IHU Marseille - Institut Hospitalier Universitaire Méditerranée Infection

Wild animals may act as efficient antimicrobial-resistance reservoirs and epidemiological links between humans, livestock, and natural environments. By using phenotypic and genotypic characterization, the present study highlighted the occurrence of an antimicrobial-resistant (i.e., amoxicillin, amoxicillin–clavulanic acid, cephalothin, and colistin) Enterobacter hormaechei subsp. steigerwaltii strain in wild boar (Sus scrofa) from France. The molecular analysis conducted showed non-synonymous mutations in the pmrA/pmrB and phoQ/phoP operons and the phoP/Q regulator mgrB gene, leading to colistin resistance. The present data highlight the need for continuous monitoring of multidrug-resistant bacteria in wild animals to limit the spread of these threatening pathogens.

Mots clés: gene inactivation; phoP/Q; pmrA/B; mgrB regulator; colistin resistance; wild boar; France

Domaines: Sciences du Vivant [q-bio]

Younes Laidoudi, Edgarthe Priscilla Ngaiganam, Jean-Lou Marié, Isabelle Pagnier, Jean-Marc Rolain, et al.. Colistin Resistance Mechanism in Enterobacter hormaechei subsp. steigerwaltii Isolated from Wild Boar (Sus scrofa) in France. Pathogens, 2022, 11 (9), pp.1022. ⟨10.3390/pathogens11091022⟩. ⟨hal-03948766⟩