ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection

Dan Corral (1, 2) , Alison Charton (1) , Maria Z Krauss (3) , Eve Blanquart (4) , Florence Levillain (1) , Emma Lefrançais (1) , Tamara Sneperger (1) , Zoï Vahlas (1) , Jean-Philippe Girard (1) , Gérard Eberl (5) , Yannick Poquet (1) , Jean-Charles Guéry (4) , Rafael J Argüello (6) , Yasmine Belkaid (2) , Katrin D Mayer-Barber (2) , Matthew R Hepworth (3) , Olivier Neyrolles (1) , Denis Hudrisier (1)

1 IPBS - Institut de pharmacologie et de biologie structurale
2 NIAID-NIH - National Institute of Allergy and Infectious Diseases [Bethesda]
3 Faculty of Biology, Medicine and Health - The Lydia Becker Institute of Immunology and Inflammation [Manchester, UK]
4 Infinity - Institut Toulousain des Maladies Infectieuses et Inflammatoires
5 Immunobiologie et Thérapie - Immunobiology and Therapy
6 CIML - Centre d'Immunologie de Marseille - Luminy

Highlights d Type 1 inflammation shapes the fate of lung IL-18Ra + ILC d IL-18Ra + ILC give rise to protective ILC1-like cells during Mtb infection d ILC1-like cells depend on glycolysis for their differentiation and function d BCG vaccination promotes the early generation of ILC1-like cells in the lung Authors

Mots clés: immunometabolism; innate lymphoid cell; mucosal immunity; tuberculosis

Domaines: Sciences du Vivant [q-bio]; Immunologie; Maladies infectieuses

Dan Corral, Alison Charton, Maria Z Krauss, Eve Blanquart, Florence Levillain, et al.. ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection. Cell Reports, 2022, 39 (3), pp.110715. ⟨10.1016/j.celrep.2022.110715⟩. ⟨hal-03951977⟩