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Article Dans Une Revue BioMed Research International Année : 2022

PEGylated Protamine Letrozole Nanoparticles: A Promising Strategy to Combat Human Breast Cancer via MCF-7 Cell Lines

PEGylated Protamine Letrozole Nanoparticles: A Promising Strategy to Combat Human Breast Cancer via MCF-7 Cell Lines.

Muhammad Tafhim Khan
  • Fonction : Auteur
Zia Uddin
  • Fonction : Auteur
Muhammad Arslan Javed
  • Fonction : Auteur
Nabi Shah
  • Fonction : Auteur
Hamid Bashir
Ahson Jabbar Shaikh
  • Fonction : Auteur
Muhammad Shahid Riaz Rajoka
Muhammad Imran Amirzada
  • Fonction : Auteur

Résumé

The objective of the study was to develop PEGylated protamine letrozole nanoparticles to combat human breast cancer by modifying the release pattern of letrozole. Breast cancer is amongst the most prevalent diseases in women due to overactivity of human epidermal growth factor receptor 2 (HER2). PEG-protamine letrozole nanoparticle formulation was designed and optimized to alter the release pattern of the drug. The size, morphology, and structure of PEG-protamine letrozole NP were characterized by FTIR, XRD, Zetasizer, and SEM analysis. The result showed the PEG-protamine letrozole nanoparticles were irregular in shape and have size ranging from 258 nm to 388 nm, polydispersity index 0.114 to 0.45, zeta potential of 11.2 mV, and entrapment efficiency 89.93%. XRD studies have confirmed that the crystal structure of letrozole has become amorphous. The drug release study maintained the prolonged release for 72 hours. Moreover, the PEG-protamine letrozole NPs displayed a strong anticancer action compared to MCF-7 cells with an IC50 70 μM for letrozole and 50 μM for PEG-protamine letrozole NPs. Overall, our results indicate that letrozole PEG-protamine NPs alter the release profile of letrozole, which could be an excellent approach for overcoming letrozole resistance in human breast cancer.

Domaines

Cancer

Dates et versions

hal-03981996 , version 1 (10-02-2023)

Identifiants

Citer

Muhammad Tafhim Khan, Zia Uddin, Muhammad Arslan Javed, Nabi Shah, Hamid Bashir, et al.. PEGylated Protamine Letrozole Nanoparticles: A Promising Strategy to Combat Human Breast Cancer via MCF-7 Cell Lines. BioMed Research International , 2022, 2022, pp.1-7. ⟨10.1155/2022/4438518⟩. ⟨hal-03981996⟩
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