Fin ray branching is defined by TRAP <sup>+</sup> osteolytic tubules in zebrafish - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2022

Fin ray branching is defined by TRAP + osteolytic tubules in zebrafish

Ana S Brandão
Joana T Rosa
Jorge Borbinha
  • Fonction : Auteur
Paulo J Almeida
  • Fonction : Auteur
António Jacinto
M. Leonor Cancela
Paulo J Gavaia
  • Fonction : Auteur
Didier y R Stainier
Vincent Laizé

Résumé

Significance Skeletal function is inherently linked to the correct shaping of the bones. However, how different cells regulate bone shaping remains unclear. The zebrafish fins are particularly suitable to study bone shaping, as bone rays undergo a simple bifurcation process, easily tracked in vivo. Here, we show that the bifurcation of a bone element relies on stitching and antistitching events, rather than on the splitting of a single unit. This report describes tartrate-resistant acid phosphatase-positive (TRAP +) osteolytic tubules and their role in bone bifurcation. Our study provides valuable insights into how cells coordinate to shape bones, thereby contributing to our understanding of bone degenerative and dysmorphic diseases and the identification of new therapeutic strategies.
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Origine : Publication financée par une institution
Licence : CC BY NC ND - Paternité - Pas d'utilisation commerciale - Pas de modification

Dates et versions

hal-04037868 , version 1 (20-03-2023)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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João Cardeira-Da-Silva, Anabela Bensimon-Brito, Marco Tarasco, Ana S Brandão, Joana T Rosa, et al.. Fin ray branching is defined by TRAP + osteolytic tubules in zebrafish. Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (48), ⟨10.1073/pnas.2209231119⟩. ⟨hal-04037868⟩

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