Curvature-Induced Cell Rearrangements in Biological Tissues - Aix-Marseille Université Accéder directement au contenu
Article Dans Une Revue Physical Review Letters Année : 2023

Curvature-Induced Cell Rearrangements in Biological Tissues

Résumé

On a curved surface, epithelial cells can adapt to geometric constraints by tilting and by exchanging their neighbors from apical to basal sides, known as an apicobasal T1 (AB-T1) transition. The relationship between cell tilt, AB-T1 transitions, and tissue curvature still lacks a unified understanding. Here, we propose a general framework for cell packing in curved environments and explain the formation of AB-T1 transitions under different conditions. We find that steep curvature gradients can lead to cell tilting and induce AB-T1 transitions. Conversely, large curvature anisotropy can drive AB-T1 transitions by hydrostatic pressure. The two mechanisms compete to determine the impact of tissue geometry and mechanics on optimized cell rearrangements in 3D.
Fichier principal
Vignette du fichier
Lou_PRL_2023_HALversion.pdf (1.47 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-04049553 , version 1 (28-03-2023)

Identifiants

Citer

Yuting Lou, Jean-Francois Rupprecht, Sophie Theis, Tetsuya Hiraiwa, Timothy E Saunders. Curvature-Induced Cell Rearrangements in Biological Tissues. Physical Review Letters, 2023, 130 (10), pp.108401. ⟨10.1103/PhysRevLett.130.108401⟩. ⟨hal-04049553⟩
18 Consultations
60 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More