, 90:10 to 85:15). 1 H NMR
, Hz, 1H), 7.87e7.78 (m, 2H), 7.56 (dt, J ¼ 7.1 Hz and 2.0 Hz, 1H), 7.50 (d, J ¼ 8.2 Hz, 1H), 7.44e7.36 (m, 3H), 7.31 (t, J ¼ 7.6 Hz, 1H), 7.08 (d, J ¼ 1.8 Hz, 1H), 6.93 (dd, J ¼ 8.3 Hz and 1.4 Hz, 1H), 4.08 (s, 2H). 13 C NMR
, , pp.47-65
,
,
, Chromatography on silica gel was eluting with CH 2 Cl 2 -MeOH (90:10 to 85:15). 1 H NMR (MeOD-d 6 , 250 MHz): d ¼ 7.94e7.91 (m, 1H), 7.79 (d, J ¼ 8.4 Hz, 2H), 7.48 (dt, J ¼ 7.0 Hz and 2.1 Hz, 1H), 7.43 (dd, J ¼ 8.3 Hz and 0.5 Hz, 1H), 7.37e7.31 (m, 2H), vol.7
, (trifluoromethyl)phenyl]carbamoyl} amino)benzenesulfonamido]butanoic acid 26, Chromatography on silica gel was eluting with CH 2 Cl 2 -MeOH (90:10). 1 H NMR, vol.7, p.47
, Hz, 1H), 7.43 (d, J ¼ 0.8 Hz, 1H), 7.42 (d, J ¼ 1.7 Hz, 1H), 7.05 (d, J ¼ 1.8 Hz, 1H), 6.90 (dd, J ¼ 8.3 Hz and 1.5 Hz, 1H), 2.87 (t, J ¼ 6.9 Hz, 2H), 2.27 (t, J ¼ 7.3 Hz, 2H), 1.68 (p, J ¼ 7.1 Hz, 2H). 13 C NMR, p.3
(trifluoromethyl)phenyl]carbamoyl} amino)benzenesulfonamido]methyl}benzoic acid 27, Chromatography on silica gel was eluting with CH 2 Cl 2 -MeOH (95:5 to 90:10). 1 H NMR (MeOD-d 6 , 400 MHz): d ¼ 10.70 (bs, 1H), 9.47 (bs, 1H), 8.87 (t, J ¼ 6.3 Hz, 1H), vol.8 ,
, , p.3
-methylpyrrolidin-3-yl)methyl]sulfamoyl}phenyl)urea 28 ,
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