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RÔLE DE L'HIPPOCAMPE DANS LA REPRÉSENTATION DU BUT Approche Comportementale et electrophysiologique

Abstract : The hippocampus plays an important role in spatial cognition, as supported by the location-specific firing of hippocampal place cells. In random foraging tasks, each place cell fires at a specific position (‘place field’) while other hippocampal pyramidal neurons remain silent. A recent study evidenced a reliable extra-field activity in most CA1 place cells of rats waiting for reward delivery in an uncued goal zone. While the location-specific activity of place cells is thought to underlie a flexible representation of space, the nature of this goal-related signal remains unclear.To test whether hippocampal goal-related activity reflects a representation of goal location or a reward-related signal, we designed a two-goal navigation task in which rats were free to choose between two uncued spatial goals to receive a reward. The magnitude of reward associated to each goal zone was modulated, therefore changing the goal value. We recorded CA1 and CA3 unit activity from rats performing this task. Behaviourally, rats were able to remember each goal location and flexibly adapt their choices to goal values. Electrophysiological data showed that a large majority of CA1-CA3 place and silent cells expressed goal-related activity. This activity was independent from goal value and rats’ behavioural choices. Importantly, a large proportion of cells expressed a goal-related activity at one goal zone only.Altogether, our findings suggest that the hippocampus processes and stores relevant information about the spatial characteristics of the goal. This goal representation could be used in cooperation with structures involved in decision-making to optimise goal-directed navigation.
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Contributor : Simon Moré Connect in order to contact the contributor
Submitted on : Monday, February 20, 2017 - 3:39:39 PM
Last modification on : Thursday, July 14, 2022 - 4:03:53 AM
Long-term archiving on: : Sunday, May 21, 2017 - 12:23:24 PM


  • HAL Id : tel-01446675, version 1


Eléonore Duvelle. RÔLE DE L'HIPPOCAMPE DANS LA REPRÉSENTATION DU BUT Approche Comportementale et electrophysiologique. Sciences cognitives. UNIVERSITÉ PIERRE ET MARIE CURIE - Paris VI, 2014. Français. ⟨tel-01446675⟩



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