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L’imagerie des gaz rares par résonance magnétique nucléaire

Abstract : Nuclear magnetic resonance (NMR) imaging of noble gases has the potential of becoming an important method for the medical diagnosis of pulmonary disease. Furthermore, the high solubility of xenon-129 in liquids might enable to use it as NMR tracer in the blood circuit. This report summarises the first steps undertaken in this laboratory concerning noble gas NMR imaging. The first part gives an overview of the properties and potential applications of noble gases in NMR imaging and spectroscopy. The second part is focused on hyperpolarisation of noble gases by means of optical pumping. The principles of the two currently used techniques are described. The design, assembly and optimisation of a xenon-129 optical pumping setup are presented as part of this work. The third part represents a theoretical approach to the optimisation of imaging sequences taking into account the properties of the noble gases. In particular, an entire chapter is dedicated to the influence of diffusion on the quality of images. Optimisation criteria for certain imaging techniques are elaborated and discussed. The last part summarises the results of in-vivo imaging experiments carried out on a rat lung. A specifically optimised pulse sequence is suggested and applied. A radiofrequency coil tuned on the helium-3 NMR frequency at 2.35 T was built. These developments have enabled to obtain the first thermal equilibrium-NMR images of helium-3 in the rat lung. Finally, a new technique for prepolarising helium-3 by cryogenic means has been realised in collaboration with the Centre de Recherche sur les Très Basses Températures in Grenoble. The technical setup as well as a first application of this method to NMR imaging of the rat lung are described.
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Contributor : Frank Kober Connect in order to contact the contributor
Submitted on : Wednesday, February 3, 2021 - 12:35:45 PM
Last modification on : Friday, March 25, 2022 - 11:09:38 AM


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  • HAL Id : tel-03130127, version 1



F. Kober. L’imagerie des gaz rares par résonance magnétique nucléaire. Imagerie. Université Joseph Fourier Grenoble, 1998. Français. ⟨tel-03130127⟩



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