Availability of Morphine Oral Solution for Childhood Cancer Patients in Low-Income Countries: Compounding and Stability Study in a Cote d'Ivoire University Teaching Hospital

Bertrand Pourroy (1, 2) , Christophe Curti (3, 4) , Edouard Lamy (5) , Jauhel N'Gbesso , Innocent Krasse , Patrice Vanelle (3, 6)

1 TIMONE - Hôpital de la Timone [CHU - APHM]
2 IGR - Institut Gustave Roussy
3 APHM - Assistance Publique - Hôpitaux de Marseille
4 AMU - Aix Marseille Université
5 ISM - Institut des Sciences du Mouvement Etienne Jules Marey
6 ICR - Institut de Chimie Radicalaire

The purpose of our study was to develop an affordable and easily available oral morphine formulation for pediatric patients with cancer pain.We devised an easy-to-make and low-cost morphine syrup formulation using local African (Cote d’Ivoire) raw materials and commercial injectable morphine. In this report, we describe the results of a study to assess the required quality controls and stability of this formulation.

Domaines: Pharmacie galénique

Bertrand Pourroy, Christophe Curti, Edouard Lamy, Jauhel N'Gbesso, Innocent Krasse, et al.. Availability of Morphine Oral Solution for Childhood Cancer Patients in Low-Income Countries: Compounding and Stability Study in a Cote d'Ivoire University Teaching Hospital. Journal of Pain and Symptom Management, 2020, 59 (1), pp.e10-e13. ⟨10.1016/j.jpainsymman.2019.10.005⟩. ⟨hal-03189262⟩