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Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy

Ramiro Vázquez 1 Maria Riveiro 2 Caroline Berenguer-Daize 3 Anthony O’kane 4 Julie Gormley 4 Olivier Touzelet 4 Keyvan Rezai 5 Mohamed Bekradda 2 l'Houcine Ouafik 3, 6
1 IIT - Istituto Italiano di Tecnologia
2 E2DG - Early Drug Development Group
3 INP - Institut de neurophysiopathologie
4 FusionAntibodies
5 Département de radio-pharmacologie
6 Laboratoire de Transfert d'Oncologie Biologique [Hôpital Nord - APHM]
Abstract : tumor angiogenesis, metastasis and growth following treatment with AM-neutralizing antibodies, AM receptor antagonists, or AM receptor interference. Anti-AM therapy is a promising strategy to be explored in oncology, not only as an anti-angiogenic alternative in the context of acquired resistance to VEGF treatment, but also as a potential antimetastatic approach.
Keywords : adrenomedullin angiogenesis cancer metastasis AM 1 and AM 2 RAMP1-3
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-03105775
Contributor : l'Houcine Ouafik <>
Submitted on : Monday, January 11, 2021 - 12:41:34 PM
Last modification on : Tuesday, January 12, 2021 - 3:29:39 AM

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Ramiro Vázquez, Maria Riveiro, Caroline Berenguer-Daize, Anthony O’kane, Julie Gormley, et al.. Targeting Adrenomedullin in Oncology: A Feasible Strategy With Potential as Much More Than an Alternative Anti-Angiogenic Therapy. Frontiers in Oncology, Frontiers, 2021, 10, ⟨10.3389/fonc.2020.589218⟩. ⟨hal-03105775⟩

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