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Journal Articles Hematological Oncology Year : 2022

Isolated intraocular relapses of primary cerebral lymphomas: An loc network study

1 Service d'Onco-neurologie = Département de neurologie 2 [CHU Pitié Salpêtrière]
2 ICSC - Institut Curie - Saint Cloud
3 U932 - Immunité et cancer
4 CHU Pitié-Salpêtrière [AP-HP]
5 Centre de recherche de l'Institut Curie [Paris]
6 Service d'Ophtalmologie [CHU Pitié-Salpêtrière]
7 Service de Biochimie Métabolique [CHU Pitié-Salpêtrière]
8 Institut Bergonié [Bordeaux]
9 INP - Institut de neurophysiopathologie
10 TIMONE - Hôpital de la Timone [CHU - APHM]
11 IUCT Oncopole - UMR 1037 - Institut Universitaire du Cancer de Toulouse - Oncopole
12 CHU Caen
13 MOBIDIC - Microenvironment and B-cells: Immunopathology,Cell Differentiation, and Cancer
14 CHU Pontchaillou [Rennes]
15 CHLS - Centre Hospitalier Lyon Sud [CHU - HCL]
16 Centre Hospitalier Le Mans (CH Le Mans)
17 Service de Neurologie [Hôpitaux Civils de Colmar]
18 CRAN - Centre de Recherche en Automatique de Nancy
19 CHRU Nancy - Centre Hospitalier Régional Universitaire de Nancy
20 CHU Angers - Centre Hospitalier Universitaire d'Angers
21 Hôpital Bretonneau
22 CHRU Tours - Centre Hospitalier Régional Universitaire de Tours
23 GPMCND - Génomique et Médecine Personnalisée du Cancer et des Maladies Neuropsychiatriques
24 CLCC Henri Becquerel - Centre de Lutte Contre le Cancer Henri Becquerel Normandie Rouen
25 CIC - Poitiers
26 CHU Amiens-Picardie
27 HEMATIM - HEMATIM - Hématopoïèse et immunologie - UR UPJV 4666
28 CHRU Brest - Centre Hospitalier Régional Universitaire de Brest
29 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]
30 HIA - Hopital d'instruction des armées Sainte-Anne [Toulon]
31 Service d'Hématologie [CH Perpignan]
32 CHU Orléans
33 Département d'Oncologie Chirurgicale [Institut Curie]
34 LITO - Laboratoire d'Imagerie Translationnelle en Oncologie
35 ICM - Institut du Cerveau = Paris Brain Institute
Gandhi Damaj
  • Function : Author
Vincent Delwail
  • Function : Author
Ibrahim Jdid
  • Function : Author


Most relapses of primary central nervous system lymphoma (PCNSL) occur in the brain and are associated with a poor prognosis. Isolated intraocular relapses (IIORs) are rare and poorly described. We retrospectively selected from the French LOC database PCNSL patients who initially presented with cerebral localization and who experienced IIOR during the course of the disease. Of the 1472 patients included in the database, 55 patients presented an IIOR. Their median age was 68 years, and median Karnofsky Performance Status 80. IL-10 levels in the aqueous humor and/or in the vitreous were increased in 42/46 patients. 45/55 patients received systemic chemotherapy, and 11/55 received high-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT) as consolidation treatment. After a median follow-up of 69 months, 42/55 patients had relapsed, including 90% of the patients who did not receive HCT-ASCT at IIOR and 40% of the patients who received HCT-ASCT at IIOR (p<0.001). The first relapse after the initial IIOR was exclusively in the eye in 23/42 patients, and 29/42 patients had a subsequent brain relapse during the course of the disease. The median progression-free survival, brain-free survival and overall survival from IIOR were 12.2, 48.6 and 57.1 months, respectively. IIOR is not exceptional in the course of PCNSL and deserves systematic ophthalmological follow-up. Its prognosis is much better than the prognosis of brain relapse, with an evolution close to that of primary vitreoretinal lymphoma. With the exception of patients who received HCT-ASCT at IIOR, almost all patients subsequently relapsed, often with other IIORs.
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Dates and versions

hal-03716518 , version 1 (16-09-2022)



Nadia Younan, Carole Soussain, Sylvain Choquet, Nathalie Cassoux, Valérie Touitou, et al.. Isolated intraocular relapses of primary cerebral lymphomas: An loc network study. Hematological Oncology, 2022, 40 (5), pp.976-986. ⟨10.1002/hon.3044⟩. ⟨hal-03716518⟩
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