Challenges in glioblastoma research: focus on the tumor microenvironment

Andreas Bikfalvi (1) , Cristine Alves da Costa (2) , Tony Avril (3, 4) , Jean-Vianney Barnier (5) , Luc Bauchet (6) , Lucie Brisson (1) , Pierre Francois Cartron (7) , Hélène Castel (8, 9) , Eric Chevet (3, 4) , Hervé Chneiweiss (10) , Anne Clavreul (11, 12) , Bruno Constantin (13) , Valérie Coronas (13) , Thomas Daubon (14) , Monique Dontenwill (15) , François Ducray (16, 17) , Natacha Enz-Werle (15) , Dominique Figarella-Branger (18) , Isabelle Fournier (19, 20) , Jean-Sébastien Frénel (8, 9) , Mathieu Gabut (16, 17) , Thierry Galli (21, 22) , Julie M Gavard (7) , Gilles Huberfeld (23) , Jean-Philippe Hugnot (6) , Ahmed Idbaih (24) , Marie-Pierre Junier (10) , Thomas Mathivet (1) , Philippe Menei (11, 12) , David Meyronet (25) , Céline Mirjolet (26, 27) , Fabrice Morin (8, 9) , Jean Mosser (3, 4) , Elisabeth Cohen-Jonathan Moyal (28, 29) , Véronique Rousseau (5) , Michel Salzet (19, 20) , Marc Sanson (24, 30) , Giorgio Seano (31) , Emeline Tabouret (32) , Aurélie Tchoghandjian (32) , Laurent Turchi (33) , François M. Vallette (7) , Somya Vats (21, 22) , Maïté Verreault (30, 24) , Thierry Virolle (33)

1 Inserm U1312 - BRIC - BoRdeaux Institute in onCology
2 IPMC - Institut de pharmacologie moléculaire et cellulaire
3 OSS - Oncogenesis, Stress, Signaling
4 CRLCC - CRLCC Eugène Marquis
5 NeuroPSI - Institut des Neurosciences Paris-Saclay
6 IGF - Institut de Génomique Fonctionnelle
7 CRCI2NA - Centre de Recherche en Cancérologie et Immunologie Intégrée Nantes-Angers
8 DC2N - Différenciation et communication neuronale et neuroendocrine
9 IRIB - Institute for Research and Innovation in Biomedicine
10 NPS - Neuroscience Paris Seine
11 CRCINA - Centre de Recherche en Cancérologie et Immunologie Nantes-Angers
12 CHU Angers - Centre Hospitalier Universitaire d'Angers
13 4CS - Canaux et Connexines dans les Cancers et Cellules Souches
14 IBGC - Institut de biochimie et génétique cellulaires
15 LBP - Laboratoire de Bioimagerie et Pathologies
16 UNICANCER/CRCL - Centre de Recherche en Cancérologie de Lyon
17 Centre Léon Bérard [Lyon]
18 Service d'Anatomie Pathologique et de Neuropathologie [Hôpital de la Timone - CHU - APHM]
19 PRISM - Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U 1192
20 CHU Lille
21 IPNP - U1266 Inserm - Institut de psychiatrie et neurosciences de Paris
22 GHU Paris Psychiatrie et Neurosciences
23 CIRB - Centre interdisciplinaire de recherche en biologie
24 ICM - Institut du Cerveau = Paris Brain Institute
25 HCL - Hospices Civils de Lyon, Departement de Neurologie
26 Equipe CADIR (LNC - U1231)
27 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]
28 CRCT - Centre de Recherches en Cancérologie de Toulouse
29 Institut Claudius Regaud
30 CHU Charles Foix [AP-HP]
31 Signalisation, radiobiologie et cancer
32 INP - Institut de neurophysiopathologie
33 IBV - Institut de Biologie Valrose

Glioblastoma (GBM) is the most deadly type of malignant brain tumor, despite extensive molecular analyses of GBM cells. In recent years, the tumor microenvironment (TME) has been recognized as an important player and therapeutic target in GBM. However, there is a need for a full and integrated understanding of the different cellular and molecular components involved in the GBM TME and their interactions for the development of more efficient therapies. In this review, we provide a comprehensive report of the GBM TME, which assembles the contributions of physicians and translational researchers working on brain tumor pathology and therapy in France. We propose a holistic view of the subject by delineating the specific features of the GBM TME at the cellular, molecular, and therapeutic levels.

Keywords: Glioblastoma; Invasion; Resistance to therapy; Tumor microenvironnement

Domains: Life Sciences [q-bio]

Andreas Bikfalvi, Cristine Alves da Costa, Tony Avril, Jean-Vianney Barnier, Luc Bauchet, et al.. Challenges in glioblastoma research: focus on the tumor microenvironment. Trends in Cancer, 2023, 9 (1), pp.9-27. ⟨10.1016/j.trecan.2022.09.005⟩. ⟨hal-03860005⟩