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Synthesis of Functionalized Spiro-Heterocycles by Sequential Multicomponent Reaction/Metal Catalyzed Carbocylizations from Simple β-Ketoesters and Amides

Hadjira Habib-Zahmani 1 Jacques Viala 1 Jean Rodriguez 1, * 
* Corresponding author
1 STeRéO
ISM2 - Institut des Sciences Moléculaires de Marseille
Abstract : A new strategy from simple cyclic β-ketoesters or amides involving a selective three-component reaction and a ring closing metathesis or a palladium catalyzed carbocyclization in a sequential fashion to access spiro-heterocycles is reported. This expedient two-step sequence generates compounds of significant molecular complexity and high synthetic and biological relevance from simple and readily available starting materials.
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Hadjira Habib-Zahmani, Jacques Viala, Jean Rodriguez. Synthesis of Functionalized Spiro-Heterocycles by Sequential Multicomponent Reaction/Metal Catalyzed Carbocylizations from Simple β-Ketoesters and Amides. SYNLETT, Georg Thieme Verlag, 2007, pp.1037-1042. ⟨10.1055/s-2007-973896⟩. ⟨hal-00676878⟩

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