Use of beta,gamma-Unsaturated alpha-Ketocarbonyls for a Totally Regioselective Oxidative Multicomponent Synthesis of Polyfunctionalized Pyridines
Résumé
α-Ketocarbonyls have been shown for the first time to be versatile partners in a Michael addition promoted oxidative domino three-component reaction under heterogeneous conditions. This multicomponent reaction sequence led to the development of a general synthesis of highly functionalized pyridines (see scheme), allowing selective and simultaneous incorporation of a substituent at the 4-position and a synthetically useful functionality at the strategic 2-position.