Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines

Christophe Allais (1) , Frédéric Liéby-Müller (1) , Thierry Constantieux (1) , Jean Rodriguez (1)

1 STeRéO

We designed a new, user-friendly oxidative dual heterogeneous catalytic system capable of promoting polysubstituted pyridines as unique products from simple activated Michael acceptors, 1,3-dicarbonyls and ammonium acetate. This metal-free environmentally-respectful and totally regioselective domino reaction proved to be a great strategy to access bi- and tri-aryl type pyridines as well as challenging bi- and tri-heteroaryl type pyridines in a single operation.

Mots clés: Biaryls; 3-/1; 2-dicarbonyls; dual heterogeneous catalysis; multicfompone; nt reactions; pyridines

Domaines: Chimie organique

Christophe Allais, Frédéric Liéby-Müller, Thierry Constantieux, Jean Rodriguez. Dual Heterogeneous Catalysis for a Regioselective Three- Component Synthesis of Bi- and Tri(hetero)arylpyridines. Advanced Synthesis and Catalysis, 2012, 354, pp.2537-2544. ⟨10.1002/adsc.201200412⟩. ⟨hal-00737327⟩