Journal articles
Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster
Abstract : Cell cycle progression is regulated by members of the cyclin-dependent kinase (CDK), Polo and Aurora families of protein kinases. The levels of expression and localization of the key regulatory kinases are themselves subject to very tight control. There is increasing evidence that crosstalk between the mitotic kinases provides for an additional level of regulation. We have previously shown that Aurora B activates Polo kinase at the centromere in mitosis, and that the interaction between Polo and the chromosomal passenger complex (CPC) component INCENP is essential in this activation. In this report, we show that Polo kinase is required for the correct localization and activity of the CPC in meiosis and mito-sis. Study of the phenotype of different polo allele combinations compared to the effect of chemical inhibition revealed significant differences in the localization and activity of the CPC in diploid tissues. Our results shed new light on the mechanisms that control the activity of Aurora B in meiosis and mitosis.
Cited literature [47 references]
https://hal-amu.archives-ouvertes.fr/hal-01243109
Contributor : Administrateur Hal Amu <>
Submitted on : Monday, December 14, 2015 - 3:20:01 PM
Last modification on : Tuesday, March 17, 2020 - 2:29:09 AM
Long-term archiving on: : Tuesday, March 15, 2016 - 1:51:26 PM
Contributor : Administrateur Hal Amu <>
Submitted on : Monday, December 14, 2015 - 3:20:01 PM
Last modification on : Tuesday, March 17, 2020 - 2:29:09 AM
Long-term archiving on: : Tuesday, March 15, 2016 - 1:51:26 PM
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