Testing the Odds of Inherent versus Observed Over-dispersion in Neural Spike Counts Odds of Inherent versus Observed Over-dispersion - Archive ouverte HAL Access content directly
Journal Articles Journal of Neurophysiology Year : 2016

Testing the Odds of Inherent versus Observed Over-dispersion in Neural Spike Counts Odds of Inherent versus Observed Over-dispersion

(1) , (1) , (2) , (1) , (1)
1
2

Abstract

The repeated presentation of an identical visual stimulus in the receptive field of a neuron may evoke different spiking patterns at each trial. Probabilistic methods are essential to understand the functional role of this variance within the neural activity. In that case, a Poisson process is the most common model of trial-to-trial variability. For a Poisson process, the variance of the spike count is constrained to be equal to the mean, irrespective of the duration of measurements. Numerous studies have shown that this relationship does not generally hold. Specifically, a majority of electrophysiological recordings show an " over-dispersion " effect: Responses that exhibit more inter-trial variability than expected from a Poisson process alone. A model that is particularly well suited to quantify over-dispersion is the Negative-Binomial distribution model. This model is well-studied and widely used but has only recently been applied to neuroscience. In this paper, we address three main issues. First, we describe how the Negative-Binomial distribution provides a model apt to account for overdispersed spike counts. Second, we quantify the significance of this model for any neurophysiological data by proposing a statistical test, which quantifies the odds that over-dispersion could be due to the limited number of repetitions (trials). We apply this test to three neurophysiological tests along the visual pathway. Finally, we compare the performance of this model to the Poisson model on a population decoding task. We show that the decoding accuracy is improved when accounting for over-dispersion, especially under the hypothesis of tuned over-dispersion.
Fichier principal
Vignette du fichier
Taouali_etal2015.pdf (870.02 Ko) Télécharger le fichier
Origin : Files produced by the author(s)

Dates and versions

hal-01396311 , version 1 (14-11-2016)

Licence

Attribution - ShareAlike - CC BY 4.0

Identifiers

Cite

Wahiba U Taouali, Giacomo U Benvenuti, Pascal U Wallisch, Frédéric U Chavane, Laurent U Perrinet. Testing the Odds of Inherent versus Observed Over-dispersion in Neural Spike Counts Odds of Inherent versus Observed Over-dispersion. Journal of Neurophysiology, 2016, 115 (1), pp.434-444. ⟨10.1152/jn.00194.2015⟩. ⟨hal-01396311⟩

Collections

CNRS UNIV-AMU INT
245 View
92 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More