Design, Synthesis and Biological evaluation of a bivalent µ opiate and adenosine A1 receptor antagonist

S. C. Mathew , N. Ghosh , Y. By , A. Berthault (1) , M.-A. Virolleaud , L. Carrega (2) , G. Chouraqui (1) , Laurent Commeiras (1) , J. Condo (2) , M. Attolini (1) , A. Gaudel-Siri (1) , J. Ruf (3) , J.-L. Parrain (1) , J. Rodriguez (1) , And R. Guieu

1 ISM2 - Institut des Sciences Moléculaires de Marseille
2 DS-ACI / UMR MD2 - Dysoxie, suractivité : aspects cellulaires et intégratifs thérapeutiques
3 UCL - University College of London [London]

Domaines: Chimie théorique et/ou physique

S. C. Mathew, N. Ghosh, Y. By, A. Berthault, M.-A. Virolleaud, et al.. Design, Synthesis and Biological evaluation of a bivalent µ opiate and adenosine A1 receptor antagonist. Bioorganic and Medicinal Chemistry Letters, 2009, 19, pp.6736. ⟨10.1016/j.bmcl.2009.09.112⟩. ⟨hal-01407732⟩