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Intranuclear expression of progesterone receptors in smooth muscle cells of renovascular fibromuscular dysplasia: a pilot study

François Silhol Gabrielle Sarlon-Bartoli 1 Laurent Daniel 2 Jean Michel Bartoli 3 Serge Cohen 4 Hubert Lepidi 5 Philippe Piquet 6 Michel Alain Bartoli Bernard Vaïsse
1 VRCM - Vascular research center of Marseille
2 HCTI - Héritages et Constructions dans le Texte et l'Image
3 CRMBM - Centre de résonance magnétique biologique et médicale
4 IMT - Institut de Mathématiques de Toulouse UMR5219
5 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes
6 Service de Chirurgie Vasculaire
Abstract : BACKGROUND: The pathogenesis of fibromuscular dysplasia (FMD) remains poorly understood. Yet, understanding this mechanism has taken on new urgency after recent evidence indicating that FMD is not as rare as previously thought. We speculated that hormonal receptors in the walls of dysplastic renal arteries were implicated in the pathogenesis of FMD. METHODS: We undertook a pilot prospective case-control study comparing histologic findings from renal arteries that were surgically removed in 2 patient groups. The case group included 6 samples from FMD patients who underwent surgery for stenosis or aneurysm caused by FMD. The control group included 3 FMD-free patients who underwent nephrectomy for nonvascular causes. Surgical specimens were sent to the histology laboratory. FMD was defined preoperatively using conventional radiologic criteria and was confirmed by histologic examination. RESULTS: Immunohistochemical staining detected intense progesterone receptor expression in the nuclei of smooth muscle cells in FMD patients. No progesterone receptor expression was found in the FMD-free patients. Estrogen receptor expression was not noted in the 2 groups. CONCLUSIONS: This preliminary finding may suggest that progesterone plays a key role in the pathogenesis of FMD and opens the fields of genetic and therapeutic approaches.
Keywords : Adult Case-Control Studies Cell Nucleus Female Fibromuscular Dysplasia Humans Immunohistochemistry Male Middle Aged Muscle Smooth Vascular Myocytes Smooth Muscle Pilot Projects Receptors Progesterone Renal Artery
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Journal articles
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https://hal-amu.archives-ouvertes.fr/hal-01414332
Contributor : Monique Bernard <>
Submitted on : Monday, December 12, 2016 - 11:38:29 AM
Last modification on : Thursday, November 12, 2020 - 9:30:07 AM

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UNIV-AMU | CNRS | UNIV-BREST | HCTI | HCTI_UBS | IMT | UNIV-TLSE2 | UBS | CRMBM | IBSHS | UNIV-TLSE3 | UT1-CAPITOLE | INSA-TOULOUSE | INSA-GROUPE

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François Silhol, Gabrielle Sarlon-Bartoli, Laurent Daniel, Jean Michel Bartoli, Serge Cohen, et al.. Intranuclear expression of progesterone receptors in smooth muscle cells of renovascular fibromuscular dysplasia: a pilot study. Annals of Vascular Surgery, Elsevier Masson, 2015, 29 (4), pp.830--835. ⟨10.1016/j.avsg.2014.10.025⟩. ⟨hal-01414332⟩

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