Is R-CHOP Therapy a Lymphoma Growth Factor?

Laure Farnault; Cédric Mercier; Yael Berda-Haddad; Gérard Sébahoun; Régis Costello

doi:10.1097/01.mjt.0000434041.54749.3d

Journal articles

Is R-CHOP Therapy a Lymphoma Growth Factor?

Laure Farnault ¹ Cédric Mercier ² Yael Berda-Haddad Gérard Sébahoun ³ Régis Costello ⁴

1 Service d’hématologie et de thérapie cellulaire

2 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie

3 Laboratoire d'Hématologie

4 TAGC - Technologies avancées pour le génôme et la clinique

Abstract : This article describes the first reported case of dramatic lymphocytosis flare after initiation of R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) therapy for an indolent lymphoma. The study patient exhibited a marginal zone lymphoma with mild nodal involvement but packed infiltration of the bone marrow. After initiation of RCHOP therapy, lymphocyte count increased from 329 to 707 x 10(9)/L at day 7. Patient exhibited grade III infusion-related side effect during rituximab therapy. Lymphocyte flare was not accompanied with other clinical manifestation such as lymph node enlargement. Because patient's bone marrow aspirate showed a packed infiltration, it was hypothesized that lymphocytosis flare was a link to lymphocyte release from bone marrow and lymphocyte demargination. This report highlights the necessity to be vigilant after initiation of RCHOP therapy for lymphoma when pathologist notified a pack infiltration of the bone marrow.

Document type :

Journal articles

Domain :

Life Sciences [q-bio]

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https://hal-amu.archives-ouvertes.fr/hal-01460124
Contributor : Lionel Spinelli <>
Submitted on : Tuesday, February 7, 2017 - 4:00:11 PM
Last modification on : Wednesday, August 19, 2020 - 12:06:27 PM

Is R-CHOP Therapy a Lymphoma Growth Factor?

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Is R-CHOP Therapy a Lymphoma Growth Factor?

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