CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response

Ariel O. Galindo-Albarran; Oscar H. Lopez-Portales; Darely Y. Gutierrez-Reyna; Otoniel Rodriguez-Jorge; Jose Antonio Sanchez-Villanueva; Oscar Ramirez-Pliego; Aurélie Bergon; Béatrice Loriod; Hélène Holota; Jean Imbert; Armando Hernandez-Mendoza; Pierre Ferrier; Enrique Carrillo-de Santa Pau; Alfonso Valencia; Salvatore Spicuglia; M. Angelica Santana

doi:10.1016/j.celrep.2016.10.056

Journal articles

CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response

Ariel O. Galindo-Albarran Oscar H. Lopez-Portales Darely Y. Gutierrez-Reyna Otoniel Rodriguez-Jorge Jose Antonio Sanchez-Villanueva Oscar Ramirez-Pliego Aurélie Bergon ¹ Béatrice Loriod ¹ Hélène Holota ² Jean Imbert ^{3, 1} Armando Hernandez-Mendoza Pierre Ferrier ⁴ Enrique Carrillo-de Santa Pau Alfonso Valencia ⁵ Salvatore Spicuglia ¹ M. Angelica Santana

1 TAGC - Technologies avancées pour le génôme et la clinique

2 EDB - Evolution et Diversité Biologique

3 TGML - Transcriptomic Genomic Marseille-Luminy

TAGC - Technologies avancées pour le génôme et la clinique

4 CIML - Centre d'Immunologie de Marseille - Luminy

5 CNIO - Spanish National Cancer Research Center

Abstract : To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8(+) T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8(+) T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8(+) T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.

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Journal articles

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Life Sciences [q-bio]

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https://hal-amu.archives-ouvertes.fr/hal-01460128
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Submitted on : Tuesday, February 7, 2017 - 4:00:20 PM
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CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response

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CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response

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