Journal articles
CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response
Ariel O. Galindo-Albarran
Oscar H. Lopez-Portales
Darely Y. Gutierrez-Reyna
Otoniel Rodriguez-Jorge
Jose Antonio Sanchez-Villanueva
Oscar Ramirez-Pliego
Aurélie Bergon
1
Béatrice Loriod
1
Hélène Holota
2
Jean Imbert
3, 1
Armando Hernandez-Mendoza
Pierre Ferrier
4
Enrique Carrillo-de Santa Pau
Alfonso Valencia
5
Salvatore Spicuglia
1
M. Angelica Santana
3
TGML - Transcriptomic Genomic Marseille-Luminy
TAGC - Technologies avancées pour le génôme et la clinique
Ariel O. Galindo-Albarran
Author
Oscar H. Lopez-Portales
Author
Darely Y. Gutierrez-Reyna
Author
Otoniel Rodriguez-Jorge
Author
Oscar Ramirez-Pliego
Author
Aurélie Bergon 1
Author IdHAL : aurelie-bergon ORCID : https://orcid.org/0000-0003-1518-4562
Béatrice Loriod 1
Author IdHAL : beatrice-loriod
Hélène Holota 2
Author
Jean Imbert 3, 1
Author
Armando Hernandez-Mendoza
Author
Pierre Ferrier 4
Author
Alfonso Valencia 5
Author
Salvatore Spicuglia 1
Author IdHAL : salvatore-spicuglia ORCID : https://orcid.org/0000-0002-8101-7108
M. Angelica Santana
Author
1
TAGC - Technologies avancées pour le génôme et la clinique (Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9 - France)
- AMU - Aix Marseille Université (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1090 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique (France)
2
EDB - Evolution et Diversité Biologique (Université Toulouse III Paul Sabatier
Bâtiment 4R1
118, route de Narbonne
31062 Toulouse cedex 9
France - France)
- CNRS - Centre National de la Recherche Scientifique : UMR5174 (France)
- IRD - Institut de Recherche pour le Développement (Siège Le Sextant 44, bd de Dunkerque CS 90009 13572 Marseille cedex 02 - France)
- UT3 - Université Toulouse III - Paul Sabatier (118 route de Narbonne - 31062 Toulouse - France)
- Université Fédérale Toulouse Midi-Pyrénées (41 Allée Jules Guesde, 31000 Toulouse - France)
3
TGML - Transcriptomic Genomic Marseille-Luminy (TAGC - Inserm UMR1090 Case 928 163 avenue de Luminy
13288 Marseille - France)
- TAGC - Technologies avancées pour le génôme et la clinique (Parc scientifique de Luminy - 163 avenue de Luminy 13288 Marseille cedex 9 - France)
- AMU - Aix Marseille Université (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1090 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique (France)
4
CIML - Centre d'Immunologie de Marseille - Luminy (Parc scientifique et technologique de Luminy - 163, avenue de Luminy - Case 906 - 13288 Marseille cedex 09 - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : UMR_S 1104 (101, rue de Tolbiac, 75013 Paris - France)
- CNRS - Centre National de la Recherche Scientifique : UMR7280 (France)
- AMU - Aix Marseille Université : UM 2 (Aix-Marseille Université Jardins du Pharo 58 Boulevard Charles Livon 13284 Marseille cedex 7 - France)
5
CNIO - Spanish National Cancer Research Center (C/ Melchor Fernández Almagro, 3 E-28029 Madrid - Spain)
Abstract : To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8(+) T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8(+) T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8(+) T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.
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https://hal-amu.archives-ouvertes.fr/hal-01460128
Contributor : Lionel Spinelli Connect in order to contact the contributor
Submitted on : Tuesday, February 7, 2017 - 4:00:20 PM
Last modification on : Wednesday, October 20, 2021 - 3:28:01 AM
Contributor : Lionel Spinelli Connect in order to contact the contributor
Submitted on : Tuesday, February 7, 2017 - 4:00:20 PM
Last modification on : Wednesday, October 20, 2021 - 3:28:01 AM
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- HAL Id : hal-01460128, version 1
- DOI : 10.1016/j.celrep.2016.10.056
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UNIV-AMU | CNRS | UNIV-TLSE3
Citation
Ariel O. Galindo-Albarran, Oscar H. Lopez-Portales, Darely Y. Gutierrez-Reyna, Otoniel Rodriguez-Jorge, Jose Antonio Sanchez-Villanueva, et al.. CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Reports, Elsevier Inc, 2016, 17 (8), pp.2151-2160. ⟨10.1016/j.celrep.2016.10.056⟩. ⟨hal-01460128⟩
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