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Journal Articles Cell Reports Year : 2016

CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response

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Abstract

To better understand why human neonates show a poor response to intracellular pathogens, we compared gene expression and histone modification profiles of neonatal naive CD8(+) T cells with that of their adult counterparts. We found that neonatal lymphocytes have a distinct epigenomic landscape associated with a lower expression of genes involved in T cell receptor (TCR) signaling and cytotoxicity and a higher expression of genes involved in the cell cycle and innate immunity. Functional studies corroborated that neonatal CD8(+) T cells are less cytotoxic, transcribe antimicrobial peptides, and produce reactive oxygen species. Altogether, our results show that neonatal CD8(+) T cells have a specific genetic program biased toward the innate immune response. These findings will contribute to better diagnosis and management of the neonatal immune response.

Dates and versions

hal-01460128 , version 1 (07-02-2017)

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Cite

Ariel O. Galindo-Albarran, Oscar H. Lopez-Portales, Darely Y. Gutierrez-Reyna, Otoniel Rodriguez-Jorge, Jose Antonio Sanchez-Villanueva, et al.. CD8(+) T Cells from Human Neonates Are Biased toward an Innate Immune Response. Cell Reports, 2016, 17 (8), pp.2151-2160. ⟨10.1016/j.celrep.2016.10.056⟩. ⟨hal-01460128⟩
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