Micelle-Based Adjuvants for Subunit Vaccine Delivery

Thomas Trimaille (1, 2) , Bernard Verrier (1)

1 LBTI - Laboratoire de Biologie Tissulaire et d'ingénierie Thérapeutique UMR 5305
2 ICR - Institut de Chimie Radicalaire

In the development of subunit vaccines with purified or recombinant antigens for cancer and infectious diseases, the design of improved and safe adjuvants able to efficiently target the antigen presenting cells, such as dendritic cells, represents a crucial challenge. Nanoparticle-based antigen delivery systems have been identified as an innovative strategy to improve the efficacy of subunit vaccines. Among them, self-assembled micellar nanoparticles from amphiphilic (macro)molecules have recently emerged as promising candidates. In this short review, we report on the recent research findings highlighting the versatility and potential of such systems in vaccine delivery.

Mots clés: micelles; antigens; amphiphilic copolymers; peptide amphiphiles

Domaines: Chimie

Thomas Trimaille, Bernard Verrier. Micelle-Based Adjuvants for Subunit Vaccine Delivery. Vaccines, 2015, 3 (4), pp.803--813. ⟨10.3390/vaccines3040803⟩. ⟨hal-01460651⟩