Genetic analysis of cortical sulci in 1,009 adults - Archive ouverte HAL Access content directly
Conference Papers Year : 2016

Genetic analysis of cortical sulci in 1,009 adults

(1) , (2) , (3) , (1) , (4) , (5) , (6) , (7) , (8) , (1)
1
2
3
4
5
6
7
8

Abstract

Specific genetic loci related to differences in brain anatomy have recently been discovered through efforts of the ENIGMA consortium and others. Yet different neuroanatomical traits may have different genetic determinants, and their discovery may offer a deeper understanding of genetic factors that shape the human brain. To investigate the degree of genetic contributions to variability in sulcal measures-the fissures within the brain's surface-1009 healthy young adult Australian twins and siblings were imaged with high-resolution 4-tesla MRI. Length, mean depth, surface area and fold openings for 60 sulci were measured for both hemispheres. We calculated the heritability for each sulcal measure (average h 2 ~0.3-0.4); genetic correlations determined if there was an overlapping genetic profile across hemispheres for the same trait, or if lateralized genetic influences were statistically distinguishable. In cases with no hemisphere-specific genetic influences, the heritability of the bilateral average was computed for greater stability.
Fichier principal
Vignette du fichier
Genetic_analysis-of-cortical.20170216pdf.pdf (1.13 Mo) Télécharger le fichier
Origin : Explicit agreement for this submission
Loading...

Dates and versions

hal-01464138 , version 1 (16-02-2017)

Identifiers

Cite

Fabrizio M Pizzagalli, Guillaume M Auzias, Peter M Kochunov, Joshua M Faskowitz, Katie M Mcmahon, et al.. Genetic analysis of cortical sulci in 1,009 adults. IEEE International Symposium on Biomedical Imaging, 2016, Prague, Czech Republic. ⟨10.1109/ISBI.2016.7493395⟩. ⟨hal-01464138⟩

Collections

CNRS UNIV-AMU INT
382 View
246 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More