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Similarity in Neuronal Firing Regimes across Mammalian Species

Yasuhiro Mochizuki 1 Tomokatsu Onaga 1 Hideaki Shimazaki 2 Takeaki Shimokawa 3 Yasuhiro Tsubo 2, 4 Rie Kimura 5 Akiko Saiki 5 Yutaka Sakai 5 Yoshikazu Isomura 5 Shigeyoshi Fujisawa 2 Ken-Ishi Shibata 1, 6 Daichi Hirai 1, 6 Takahiro Furuta 1, 6 Takeshi Keneko 1, 5 Susumu Takahashi 7 Tomaoki Nakazono 7 Seiya Ishino 8 Yoshio Sakurai 7 Takashi Kitsukawa 9 Jong Won Lee 10 Huynjung Lee 11 Min Whan Jung 12, 10 Cecilia Babul 13 Pedro E. Maldonado 13 Kazutaka Takahashi 14, 15 Fritzie I. Arce-Macshane 15 Callum F. Ross 15, 14 Barry J.Sessle 15, 14 Nicolas G. Hatsopoulos 15 Thomas Brochier 16 Alexa Riehle 17, 16 Paul Chorley 17 Sonja Grün 18, 19 Hisao Nishijo 20 Satoe Ichihara - Takeda 21 Shinraro Funahashi 22 Keisetsu Shima 23 Hajima Mushiake 23 Yukako Yamane 24, 9 Hiroshi Tamura 25 Ishiro Fujita 24 Naoko Inaba 6 Kenji Kawano 6 Sergei Kurkin 26 Kikuro Fukushima 26 Kurata Kiyoshi 27 Masato Taira 28 Ken-Ichiro Tsutsui 29 Tadashi Ogawa 30 Komatsu Hidehiko 3 Kowa Koida 25 Keisuke Toyama 3 Barry J. Richmond 31, 32 Shigeru Shinomoto 1
Abstract : The architectonic subdivisions of the brain are believed to be functional modules, each processing parts of global functions. Previously, we showed that neurons in different regions operate in different firing regimes in monkeys. It is possible that firing regimes reflect differences in underlying information processing, and consequently the firing regimes in homologous regions across animal species might be similar. We analyzed neuronal spike trains recorded from behaving mice, rats, cats, and monkeys. The firing regularity differed systematically, with differences across regions in one species being greater than the differences in similar areas across species. Neuronal firing was consistently most regular in motor areas, nearly random in visual and prefrontal/medial prefrontal cortical areas, and bursting in the hippocampus in all animals examined. This suggests that firing regularity (or irregularity) plays a key role in neural computation in each functional subdivision, depending on the types of information being carried. By analyzing neuronal spike trains recorded from mice, rats, cats, and monkeys, we found that different brain regions have intrinsically different firing regimes that are more similar in homologous areas across species than across areas in one species. Because different regions in the brain are specialized for different functions, the present finding suggests that the different activity regimes of neurons are important for supporting different functions, so that appropriate neuronal codes can be used for different modalities.
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Yasuhiro Mochizuki, Tomokatsu Onaga, Hideaki Shimazaki, Takeaki Shimokawa, Yasuhiro Tsubo, et al.. Similarity in Neuronal Firing Regimes across Mammalian Species. Journal of Neuroscience, Society for Neuroscience, 2016, 36, pp.5736-5747. ⟨10.1523/JNEUROSCI.0230-16.2016⟩. ⟨hal-01464205⟩

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