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Chromosomal localization of human homologs of the drosophila heterochromatin protein-1 (hp1) gene

Abstract : Modifiers of hetero-chromatin. (PEV) and members of the Polycomb-group (Pc-group) gencs en-code proteins that are thought to modify chromatin, rendering it heritably changed in its expressibility (Gaunt and Singh 1990; Paro 1990). Isolation and se-quencing of the PC-group namesake, Polycomb (Pc), has revealed a region of homology with a modifier of PEY known as heterochromatin protein 1 (HPI) (Paro and Hogness 1991). We have shown that the region of homology shared by HPl and Pc, termcd chromo box, can be used to detect homologous sequences in a wide range of animal and plant species (Singh et al. 1991). In addition, this conserved motif has been used to clone the first chromobox-containing genes from mouse (M31 and M32) and human (HSMJ). We have argued that the mammalian HPl-like genes might fonction as gene repressors in a manner similar to their fly ho-molog, perhaps by serving as components of hetero-chromatin.
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Christophe Chevillard, Wolf Reik, Mickael Mc Dermott, Michel Fontes, Marie Geneviève Mattei, et al.. Chromosomal localization of human homologs of the drosophila heterochromatin protein-1 (hp1) gene. Mammalian Genome, Springer Verlag, 1993, 4 (2), pp.124-126. ⟨10.1007/BF00290438⟩. ⟨hal-01593102⟩

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