The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells

Abstract : In order to understand the mechanisms supporting steroid escape in patients with multiple myeloma (MM), three IL-6 autocrine human myeloma cell lines, LP1, OPM2 and L363, have been treated with dexamethasone in the presence or absence of cytokines belonging to the gp 130 family: IL-6, LIF, OSM and IL-11. With pharmacological doses of dexamethasone, a dramatic growth arrest was observed in all the cell lines. IL-6 completely reversed this inhibition. Of note, this IL-6 induced reversion was still seen with very low amounts of IL-6 (12 pg/ml). Finally, whereas LIF and OSM had clear growth-promoting effects on OPM2 only, both cytokines (but not IL-11) reversed the dexamethasone-induced growth arrest in all the cell lines. Therefore the high levels of IL-6 (ng/ml) observed in the MM intermediate milieu and the putative presence of LIF and OSM can easily counteract the effects of dexamethasone in vivo.
Type de document :
Article dans une revue
Br. J. Haematol., 1995, 90 (3), pp.707--710
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Contributeur : Lionel Spinelli <>
Soumis le : mercredi 27 septembre 2017 - 09:28:49
Dernière modification le : mardi 30 janvier 2018 - 01:29:52

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  • HAL Id : hal-01595838, version 1

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N. Juge-Morineau, S. François, Denis Puthier, A. Godard, R. Bataille, et al.. The gp 130 family cytokines IL-6, LIF and OSM but not IL-11 can reverse the anti-proliferative effect of dexamethasone on human myeloma cells. Br. J. Haematol., 1995, 90 (3), pp.707--710. 〈hal-01595838〉

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