Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

Irmina Diala; Nicole Wagner; Frédérique Magdinier; Marina Shkreli; Maria Sirakov; Serge Bauwens; Caroline Schluth-Bolard; Thomas Simonet; Valérie Renault; Jing Ye; Abdelnnadir Djerbi; Pascal Pineau; Jinkuk Choi; Steven Artandi; Anne Dejean; Michelina Plateroti; Eric Gilson

doi:10.1038/embor.2013.16

Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

Irmina Diala Nicole Wagner ¹ Frédérique Magdinier ² Marina Shkreli Maria Sirakov Serge Bauwens Caroline Schluth-Bolard Thomas Simonet Valérie Renault Jing Ye Abdelnnadir Djerbi Pascal Pineau Jinkuk Choi Steven Artandi Anne Dejean Michelina Plateroti Eric Gilson

1 IBDM - Institut de Biologie du Développement de Marseille

2 GMGF - Génétique Médicale et Génomique Fonctionnelle

Abstract : The DNA-binding protein TRF2 is essential for telomere protection and chromosome stability in mammals. We show here that TRF2 expression is activated by the Wnt/b-catenin signalling pathway in human cancer and normal cells as well as in mouse intestinal tissues. Furthermore, b-catenin binds to TRF2 gene regulatory regions that are functional in a luciferase transactivat-ing assay. Reduced b-catenin expression in cancer cells triggers a marked increase in telomere dysfunction, which can be reversed by TRF2 overexpression. We conclude that the Wnt/b-catenin signalling pathway maintains a level of TRF2 critical for telomere protection. This is expected to have an important role during development, adult stem cell function and oncogenesis.

Keywords : cancer telomere TRF2 Wnt signalling

Type de document :

Article dans une revue

EMBO Reports, EMBO Press, 2013, 14 (4), pp.356 - 363. 〈10.1038/embor.2013.16〉

Domaine :

Sciences du Vivant [q-bio] / Génétique

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https://hal-amu.archives-ouvertes.fr/hal-01663630
Contributeur : Frederique Magdinier <>
Soumis le : jeudi 14 décembre 2017 - 10:15:28
Dernière modification le : lundi 27 août 2018 - 09:44:38

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Telomere protection and TRF2 expression are enhanced by the canonical Wnt signalling pathway

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