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Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight

Abstract : Vitamin E is an essential fat-soluble micronutrient whose effects on human health can be attributed to both antioxidant and non-antioxidant properties. A growing number of studies aim to promote vitamin E bioavailability in foods. It is thus of major interest to gain deeper insight into the mechanisms of vitamin E absorption, which remain only partly understood. It was long assumed that vitamin E was absorbed by passive diffusion, but recent data has shown that this process is actually far more complex than previously thought. This review describes the fate of vitamin E in the human gastrointestinal lumen during digestion and focuses on the proteins involved in the intestinal membrane and cellular transport of vitamin E across the enterocyte. Special attention is also given to the factors modulating both vitamin E micellarization and absorption. Although these latest results significantly improve our understanding of vitamin E intestinal absorption, further studies are still needed to decipher the molecular mechanisms driving this multifaceted process.
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Submitted on : Friday, March 30, 2018 - 4:59:47 PM
Last modification on : Tuesday, May 26, 2020 - 8:52:41 PM

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Emmanuelle Reboul. Vitamin E Bioavailability: Mechanisms of Intestinal Absorption in the Spotlight. Antioxidants and Redox Signaling, Mary Ann Liebert, 2017, 6 (4), pp.1-11. ⟨10.3390/antiox6040095⟩. ⟨hal-01755702⟩

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