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TGF beta R signalling controls CD103(+)CD11b(+) dendritic cell development in the intestine

Abstract : CD103(+)CD11b(+) dendritic cells (DCs) are unique to the intestine, but the factors governing their differentiation are unclear. Here we show that transforming growth factor receptor 1 (TGF beta beta R1) has an indispensable, cell intrinsic role in the development of these cells. Deletion of Tgfbr1 results in markedly fewer intestinal CD103(+)CD11b(+) DCs and a reciprocal increase in the CD103(-)CD11b(+) dendritic cell subset. Transcriptional profiling identifies markers that define the CD103(+)CD11b(+) DC lineage, including CD101, TREM1 and Siglec-F, and shows that the absence of CD103(+)CD11b(+) DCs in CD11c-Cre. Tgfbr1(fl/fl) mice reflects defective differentiation from CD103(-)CD11b(+) intermediaries, rather than an isolated loss of CD103 expression. The defect in CD103(+)CD11b(+) DCs is accompanied by reduced generation of antigen-specific, inducible FoxP3(+) regulatory T cells in vitro and in vivo, and by reduced numbers of endogenous Th17 cells in the intestinal mucosa. Thus, TGF beta R1-mediated signalling may explain the tissue-specific development of these unique DCs.
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Submitted on : Friday, April 13, 2018 - 11:09:55 AM
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C. C. Bain, J. Montgomery, C. L. Scott, J. M. Kel, M. J. H. Girard-Madoux, et al.. TGF beta R signalling controls CD103(+)CD11b(+) dendritic cell development in the intestine. Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-00658-6⟩. ⟨hal-01764675⟩

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