Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry - Archive ouverte HAL Access content directly
Journal Articles Journal of Immunology Year : 2017

Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry

(1) , (1) , (1) , (2) , (2) , (3) , (2) , (2) , (1)
1
2
3

Abstract

Sustained Ca2+ signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8(+) T cells require sustained Ca2+ signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for SOCE, to examine the contribution of sustained Ca2+ signaling to murine NK cell function. Surprisingly, we found that, although SOCE is required for NK cell IFN-gamma production in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in vivo remained intact in the absence of sustained Ca2+ signaling. Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes.

Dates and versions

hal-01765105 , version 1 (12-04-2018)

Identifiers

Cite

Jacquelyn Freund-Brown, Ruth Choa, Brenal K. Singh, Tanner Ford Robertson, Gabrielle M. Ferry, et al.. Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. Journal of Immunology, 2017, 199 (6), pp.1973-1978. ⟨10.4049/jimmunol.1700340⟩. ⟨hal-01765105⟩

Collections

CNRS UNIV-AMU
18 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More