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Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry

Abstract : Sustained Ca2+ signaling, known as store-operated calcium entry (SOCE), occurs downstream of immunoreceptor engagement and is critical for cytotoxic lymphocyte signaling and effector function. CD8(+) T cells require sustained Ca2+ signaling for inflammatory cytokine production and the killing of target cells; however, much less is known about its role in NK cells. In this study, we use mice deficient in stromal interacting molecules 1 and 2, which are required for SOCE, to examine the contribution of sustained Ca2+ signaling to murine NK cell function. Surprisingly, we found that, although SOCE is required for NK cell IFN-gamma production in an NFAT-dependent manner, NK cell degranulation/cytotoxicity and tumor rejection in vivo remained intact in the absence of sustained Ca2+ signaling. Our data suggest that mouse NK cells use different signaling mechanisms for cytotoxicity compared with other cytotoxic lymphocytes.
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https://hal-amu.archives-ouvertes.fr/hal-01765105
Contributor : Carine Dou Goarin <>
Submitted on : Thursday, April 12, 2018 - 3:39:13 PM
Last modification on : Wednesday, January 29, 2020 - 11:10:04 AM

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Jacquelyn Freund-Brown, Ruth Choa, Brenal K. Singh, Tanner Ford Robertson, Gabrielle M. Ferry, et al.. Cutting Edge: Murine NK Cells Degranulate and Retain Cytotoxic Function without Store-Operated Calcium Entry. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2017, 199 (6), pp.1973-1978. ⟨10.4049/jimmunol.1700340⟩. ⟨hal-01765105⟩

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