Journal articles
Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons
Abstract : Integration of synaptic excitation to generate an action potential (excitatory postsynaptic potential-spike coupling or E-S coupling) determines the neuronal output. Bidirectional synap-tic plasticity is well established in the hippocampus, but whether active synaptic integration can display potentiation and depression remains unclear. We show here that synaptic depression is associated with an N-methyl-D-aspartate receptor-dependent and long-lasting depression of E-S coupling. E-S depression is input-specific and is expressed in the presence of-aminobutyric acid type A and B receptor antagonists. In single neurons, E-S depression is observed without modification of postsynaptic passive properties. We conclude that a decrease in intrinsic excitability underlies E-S depression and is synergic with gluta-matergic long-term depression.
Cited literature [21 references]
https://hal-amu.archives-ouvertes.fr/hal-01766854
Contributor : Dominique Debanne Connect in order to contact the contributor
Submitted on : Saturday, April 14, 2018 - 1:14:48 PM
Last modification on : Friday, October 22, 2021 - 3:26:50 AM
Contributor : Dominique Debanne Connect in order to contact the contributor
Submitted on : Saturday, April 14, 2018 - 1:14:48 PM
Last modification on : Friday, October 22, 2021 - 3:26:50 AM
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Daoudal-Debanne-PNAS-2002.pdf
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