Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons

Gaël Daoudal , Yasuhiro Hanada (1) , Dominique Debanne (2)

1 Department of Psychology [Yokohama]
2 UNIS - Inserm U1072 - Unité de Neurobiologie des canaux Ioniques et de la Synapse

Integration of synaptic excitation to generate an action potential (excitatory postsynaptic potential-spike coupling or E-S coupling) determines the neuronal output. Bidirectional synap-tic plasticity is well established in the hippocampus, but whether active synaptic integration can display potentiation and depression remains unclear. We show here that synaptic depression is associated with an N-methyl-D-aspartate receptor-dependent and long-lasting depression of E-S coupling. E-S depression is input-specific and is expressed in the presence of-aminobutyric acid type A and B receptor antagonists. In single neurons, E-S depression is observed without modification of postsynaptic passive properties. We conclude that a decrease in intrinsic excitability underlies E-S depression and is synergic with gluta-matergic long-term depression.

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology

Gaël Daoudal, Yasuhiro Hanada, Dominique Debanne. Bidirectional plasticity of excitatory postsynaptic potential (EPSP)-spike coupling in CA1 hippocampal pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America, 2002, 99 (22), pp.14512-14517. ⟨10.1073/pnas.222546399⟩. ⟨hal-01766854⟩