Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data

Coralie Di Scala (1) , Nouara Yahi (1) , Alessandra Flores (1) , Sonia Boutemeur (1) , Nazim Kourdougli (2) , Henri Chahinian (1) , Jacques Fantini (1)

1 PPSN - Physiologie et physiopathologie du système nerveux somato-moteur et neurovégétatif
2 INMED - INSERM U901 - Institut de Neurobiologie de la Méditerranée [Aix-Marseille Université]

The data here consists of calcium imaging of human neuro-blastoma SH-SY5Y cells treated with the calcium-sensitive dye Fluo-4AM and then incubated with nanomolar concentrations of either human or rat Alzheimer's β-amyloid peptide Aβ1-42. These data are both of a qualitative (fluorescence micrographs) and semi-quantitative nature (estimation of intracellular calcium concentrations of cells probed by Aβ1-42 peptides vs. control untreated cells). Since rat Aβ1-42 differs from its human counterpart at only three amino acid positions, this comparative study is a good assessment of the specificity of the amyloid pore forming assay. The interpretation of this dataset is presented in the accompanying study " Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson pep-tide targeting brain gangliosides " [1].

Domains: Life Sciences [q-bio]; Neurons and Cognition [q-bio.NC]; Neurobiology

Coralie Di Scala, Nouara Yahi, Alessandra Flores, Sonia Boutemeur, Nazim Kourdougli, et al.. Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data. Data in Brief, 2014, 6, pp.640-643. ⟨10.1016/j.dib.2016.01.019⟩. ⟨hal-01768262⟩