Familial and syndromic lupus share the same phenotype as other early-onset forms of lupus.
(1)
,
(1)
,
(2)
,
(3, 4)
,
(5)
,
(4)
,
(6)
,
(7)
,
(8)
,
(9)
,
(9)
,
(9)
,
(9)
,
(10)
,
(10)
,
(11)
,
(11)
,
(11)
,
(12)
,
(13)
,
(14)
,
(15)
,
(16)
,
(17)
,
(18)
,
(2)
,
(19)
,
(20)
,
(21)
,
(22, 23)
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
Christophe Malcus
- Function : Author
- PersonId : 909975
Behrouz Kassai
- Function : Author
- PersonId : 178676
- IdHAL : behrouzkassai
- ORCID : 0000-0002-1712-120X
- IdRef : 133741699
Yanick Crow
- Function : Author
- PersonId : 11918
- IdHAL : yanick-crow
- ORCID : 0000-0001-7211-7564
- IdRef : 227205359
Isabelle Kone-Paut
- Function : Author
- PersonId : 947672
Maryam Piram
- Function : Author
- PersonId : 947671
Caroline Galeotti
- Function : Author
- PersonId : 947669
Héloïse Reumaux
- Function : Author
- PersonId : 791276
- ORCID : 0000-0001-5682-4760
Stéphane Burtey
- Function : Author
- PersonId : 183685
- IdHAL : stephane-burtey
- IdRef : 111036372
Irène Lemelle
- Function : Author
- PersonId : 770246
- ORCID : 0000-0002-8761-2020
Ulrich Meinzer
- Function : Author
- PersonId : 784468
- ORCID : 0000-0001-8539-6507
Brigitte Bader-Meunier
- Function : Author
- PersonId : 910470
Alexandre Belot
- Function : Author
- PersonId : 781111
- ORCID : 0000-0003-4902-5332
- IdRef : 115823824
Abstract
Studies of early-onset systemic lupus erythematosus (SLE) have identified monogenic forms of the disease. The primary objective of this study was to compare the clinical and laboratory features of the first patients included in the GENIAL/LUMUGENE cohort to those reported in previous publications. The secondary objective was to determine whether subgroups with a distinctive pattern of clinical and biological features are seen in predominantly genetic forms of SLE.