Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child.

M. Beye (1) , K. El Karkouri (1) , N. Labas , Didier Raoult (1) , Pierre-Edouard Fournier (1)

1 URMITE - Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes

We sequenced the genome of Streptococcus pyogenes strain G773 that caused an infective endocarditis in a 4-year-old boy suffering from acute endocarditis. The 1.9-Mb genome exhibited a specific combination of virulence factors including a complete integrative and conjugative element, sp2905, previously described as incomplete in S. pyogenes, and five bacteriocin-coding genes. However, strain G773 lacked a CRISPR-Cas system.

Keywords: Endocarditis; genome comparison; real-time genome sequencing; Streptococcus pyogenes; virulence

Domains: Life Sciences [q-bio]; Microbiology and Parasitology

M. Beye, K. El Karkouri, N. Labas, Didier Raoult, Pierre-Edouard Fournier. Genomic analysis of a Streptococcus pyogenes strain causing endocarditis in a child.. New Microbes and New Infections, 2017, 17, pp.1--6. ⟨10.1016/j.nmni.2017.01.007⟩. ⟨hal-01795941⟩