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Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.

P. Giraud 1 M Maltèse 1 F. Boudouresque 1 P. Salers 1 L Ouafik 1 M. Renard 1 F. Pelen 1 C. Oliver 1
1 INSERM U 297 - Laboratoire de Neuroendocrinologie Expérimentale
Abstract : Carboxy-terminal amidation of biologically active peptides, an important characteristic of more than half of these substances, occurs during the maturation process of peptide precursors. It is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme that is copper-dependent. We show here that alterations of copper stores in cultured cells from different origins (pancreas and hypothalamus) affect the immunoreactivity of thyrotropin-releasing hormone (TRH) and corticotropin-releasing factor (CRF) (two alpha-amidated peptides). This suggests that copper can affect neuropeptide biosynthesis and may play a role in the endocrine or central nervous system function.
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Submitted on : Wednesday, May 30, 2018 - 1:57:25 PM
Last modification on : Thursday, May 31, 2018 - 1:09:57 AM

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  • HAL Id : hal-01803479, version 1
  • PUBMED : 1375068

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P. Giraud, M Maltèse, F. Boudouresque, P. Salers, L Ouafik, et al.. Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.. Biological Trace Element Research, Humana Press, 1992, pp.293-301. ⟨hal-01803479⟩

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