Skip to Main content Skip to Navigation
Journal articles

Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.

Abstract : Carboxy-terminal amidation of biologically active peptides, an important characteristic of more than half of these substances, occurs during the maturation process of peptide precursors. It is catalyzed by peptidylglycine alpha-amidating monooxygenase (PAM), an enzyme that is copper-dependent. We show here that alterations of copper stores in cultured cells from different origins (pancreas and hypothalamus) affect the immunoreactivity of thyrotropin-releasing hormone (TRH) and corticotropin-releasing factor (CRF) (two alpha-amidated peptides). This suggests that copper can affect neuropeptide biosynthesis and may play a role in the endocrine or central nervous system function.
Document type :
Journal articles
Complete list of metadatas

https://hal-amu.archives-ouvertes.fr/hal-01803479
Contributor : l'Houcine Ouafik <>
Submitted on : Wednesday, May 30, 2018 - 1:57:25 PM
Last modification on : Thursday, May 31, 2018 - 1:09:57 AM

Identifiers

  • HAL Id : hal-01803479, version 1
  • PUBMED : 1375068

Collections

Citation

P. Giraud, M Maltèse, F. Boudouresque, P. Salers, L Ouafik, et al.. Peptidylglycine alpha-amidating monooxygenase activity and TRH and CRF biosynthesis. Role of copper.. Biological Trace Element Research, Humana Press, 1992, pp.293-301. ⟨hal-01803479⟩

Share

Metrics

Record views

18