A Bird's Eye View of Atropisomers Featuring a Five-Membered Ring

Damien Bonne (1) , Jean Rodriguez (1)

1 ISM2 - Institut des Sciences Moléculaires de Marseille

An atropisomer is a member of a subclass of restricted rotational conformers-this restricted rotation giving rise to stereogenic sigma bonds-that can be isolated as separate chemical species. Most atropisomer are six-membered-ring biaryl or heterobiaryl derivatives. The aim of this microreview is to shed light on a less common class of atropisomers, those containing at least one five-membered hetero-or carbocycle and displaying variously a stereogenic C-N, CC , or even N-N

Mots clés: Atropisomerism; Five-membered ring atropisomers; Ligand design; Natural products; Organocatalysis; Rotational barriers

Domaines: Chimie organique

Damien Bonne, Jean Rodriguez. A Bird's Eye View of Atropisomers Featuring a Five-Membered Ring. European Journal of Organic Chemistry, 2018, 2018 (20-21), pp.2417 - 2431. ⟨10.1002/ejoc.201800078⟩. ⟨hal-01907622⟩